TargetMol

CAY10748

Product Code:
 
TAR-T36461
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36461-5mg5mg£1,091.00
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TAR-T36461-50mg50mg£2,143.00
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TAR-T36461-100mg100mg£2,801.00
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Further Information

Bioactivity:
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 μM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.
CAS:
2412902-55-5
Formula:
C30H37N7O6
Molecular Weight:
591.7
Purity:
0.98
SMILES:
NC(C1=CC(OCCCOC)=C(N(CCCNC(OCC2=CC=CC=C2)=O)C(NC(C3=CC(C)=NN3CC)=O)=N4)C4=C1)=O

References

Xi, Q., Wang, M., Jia, W., et al.Design, synthesis, and biological evaluation of amidobenzimidazole derivatives as stimulator of interferon genes (STING) receptor agonistsJ. Med. Chem.63(1)260-282(2019)