TargetMol

(Rac)-SAR131675

Product Code:
 
TAR-T3691
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3691-1mg1mg£111.00
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TAR-T3691-5mg5mg£161.00
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TAR-T3691-10mg10mg£203.00
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TAR-T3691-25mg25mg£291.00
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TAR-T3691-50mg50mg£389.00
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Quantity:
TAR-T3691-100mg100mg£547.00
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Further Information

Bioactivity:
SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
CAS:
1092539-44-0
Formula:
C18H22N4O4
Molecular Weight:
358.398
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.991
SMILES:
CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)COC
Target:
VEGFR

References

Alam A, et al. Mol Cancer Ther, 2012, 11(8), 1637-1649.