TargetMol

Pepstatin

Product Code:
 
TAR-T3695
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3695-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T3695-10mg10mg£109.00
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TAR-T3695-25mg25mg£153.00
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TAR-T3695-50mg50mg£204.00
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TAR-T3695-100mg100mg£297.00
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TAR-T3695-200mg200mg£409.00
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This product comes from: United States.
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Further Information

Bioactivity:
Pepstatin is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
CAS:
26305-03-3
Formula:
C34H63N5O9
Molecular Weight:
685.904
Pathway:
Microbiology/Virology; Ubiquitination; Metabolism; Proteases/Proteasome; Autophagy
Purity:
0.9994
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(O)=O
Target:
Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy

References

Kim JH, et al. Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. PLoS One. 2018 Nov 8;13(11):e0207090. Jiang T Y, Feng X F, Fang Z, et al. PTEN deficiency facilitates the therapeutic vulnerability to proteasome inhibitor bortezomib in gallbladder cancer[J]. Cancer Letters. 2020 Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62. Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6612-6. Jiang T Y, Feng X F, Fang Z, et al. PTEN deficiency facilitates the therapeutic vulnerability to proteasome inhibitor bortezomib in gallbladder cancer. Cancer Letters. 2021, 501: 187-199. Schreiber S, et al. Rapid loss of motility of Helicobacter pylori in the gastric lumen in vivo. Infect Immun. 2005 Mar;73(3):1584-9.