TargetMol

CAY10771

Product Code:
 
TAR-T37414
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37414-5mg5mg£850.00
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TAR-T37414-50mg50mg£1,661.00
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TAR-T37414-100mg100mg£2,079.00
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Further Information

Bioactivity:
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM.
CAS:
2522599-79-5
Formula:
C28H25Cl3N2O4
Molecular Weight:
559.9
Purity:
0.98
SMILES:
ClC1=CC=CC(Cl)=C1C2=NOC(C(C)C)=C2COC3=CC(Cl)=C(CNC4=CC=C(CC(O)=O)C=C4)C=C3

References

Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPAR? activatorsJ. Med. Chem.63(15)8369-8379(2020)