TargetMol

LM10

Product Code:
 
TAR-T4410
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4410-1mL1 mL * 10 mM (in DMSO)£95.00
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TAR-T4410-5mg5mg£95.00
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TAR-T4410-10mg10mg£108.00
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TAR-T4410-25mg25mg£148.00
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TAR-T4410-50mg50mg£209.00
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TAR-T4410-100mg100mg£340.00
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TAR-T4410-200mg200mg£494.00
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TAR-T4410-500mg500mg£747.00
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This product comes from: United States.
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Further Information

Bioactivity:
Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.
CAS:
1316695-35-8
Formula:
C11H8FN5
Molecular Weight:
229.218
Purity:
0.9994
SMILES:
Fc1ccc2c(C=Cc3nnn[nH]3)c[nH]c2c1

References

Huang W,etal.Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism.J Struct Biol. 2013 Mar;181(3):291-9. Pilotte L,etal.Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase.Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2497-502.