TargetMol

Tirapazamine

Product Code:
 
TAR-T4434
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4434-10mg10mg£95.00
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TAR-T4434-25mg25mg£108.00
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TAR-T4434-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4434-50mg50mg£119.00
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TAR-T4434-100mg100mg£152.00
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TAR-T4434-200mg200mg£201.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tirapazamine is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.
CAS:
27314-97-2
Formula:
C7H6N4O2
Molecular Weight:
178.151
Purity:
0.9987
SMILES:
Nc1n[n+]([O-])c2ccccc2[n+]1[O-]

References

Cai T Y, Liu X W, Zhu H, et al. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1?[J]. Molecular cancer therapeutics, 2013: molcanther. 0490.2013. Liu C, Jia S, Tu L, et al. GSH-Responsive and Hypoxia-Activated Multifunctional Nanoparticles for Synergetically Enhanced Tumor Therapy. ACS Biomaterials Science & Engineering. 2022 Sliwinska J, Dudka J, Korga A, et al. Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca< sup> 2[J]. Oxidative medicine and cellular longevity, 2012, 2012. Wu Z, Wang Y, Li L, et al.New insights into the antimicrobial action and protective therapeutic effect of tirapazamine towards Escherichia coli-infected mice.International Journal of Antimicrobial Agents.2023: 106923.