TargetMol

PJ34

Product Code:
 
TAR-T6197
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6197-10mg10mg£109.00
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Quantity:
TAR-T6197-1mL1 mL * 10 mM (in DMSO)£123.00
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TAR-T6197-25mg25mg£142.00
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TAR-T6197-50mg50mg£189.00
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Quantity:
TAR-T6197-100mg100mg£262.00
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This product comes from: United States.
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Further Information

Bioactivity:
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
CAS:
344458-19-1
Formula:
C17H17N3O2
Molecular Weight:
295.342
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9985
SMILES:
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1
Target:
PARP

References

Haddad M, et al. Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149(1):23-30. Iwashita A, et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph Hussain M, Lu Y, Tariq M, et al. A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism. Iscience. 2022, 25(7): 104591.