TargetMol

Monomethyl auristatin E

Product Code:
 
TAR-T6897
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6897-10mg10mg£103.00
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TAR-T6897-25mg25mg£122.00
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TAR-T6897-50mg50mg£144.00
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This product comes from: United States.
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Further Information

Bioactivity:
Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
CAS:
474645-27-7
Formula:
C39H67N5O7
Molecular Weight:
717.993
Pathway:
Cytoskeletal Signaling; Apoptosis
Purity:
0.9966
SMILES:
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
Target:
Apoptosis; Microtubule Associated

References

Ai Y, Wang W, Liu F, et al.Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.Cell Research.2023: 1-19. Francisco JA, et al. Blood. 2003, 102(4), 1458-1465. Dornan D, et al. Blood. 2009, 114(13), 2721-2729. Yao X, et al. Breast Cancer Res Treat. 2015, 153(1), 123-133.