TargetMol

Flavokawain B

Product Code:
 
TAR-T6S0735
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6S0735-1mg1mg£124.00
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TAR-T6S0735-5mg5mg£201.00
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TAR-T6S0735-10mg10mg£282.00
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TAR-T6S0735-25mg25mg£430.00
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TAR-T6S0735-50mg50mg£589.00
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TAR-T6S0735-100mg100mg£784.00
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Quantity:
TAR-T6S0735-500mg500mg£1,508.00
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Further Information

Bioactivity:
1. Flavokawain B has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
CAS:
1775-97-9
Formula:
C17H16O4
Molecular Weight:
284.311
Pathway:
; Apoptosis
Purity:
1
SMILES:
COc1cc(O)c(C(=O)C=Cc2ccccc2)c(OC)c1
Target:
Apoptosis;

References

Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021?1781 Zhang T , Yamamoto N , Yamashita Y , et al. The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK[J]. Archives of Biochemistry and Biophysics, 2014, 554:44-54.