TargetMol

VU0119498

Product Code:
 
TAR-T8224
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T8224-10mg10mg£109.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8224-1mL1 mL * 10 mM (in DMSO)£115.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8224-25mg25mg£141.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8224-50mg50mg£178.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8224-100mg100mg£230.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8224-200mg200mg£309.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
CAS:
79183-37-2
Formula:
C15H10BrNO2
Molecular Weight:
316.15
Pathway:
Neuroscience
Purity:
1
SMILES:
Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Target:
AChR

References

Lu Zhu , Mario Rossi,et al.Allosteric Modulation of ?-Cell M 3 Muscarinic Acetylcholine Receptors Greatly Improves Glucose Homeostasis in Lean and Obese Mice.Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. Thomas M Bridges,et al.Heterobiaryl and Heterobiaryl Ether Derived M5 Positive Allosteric Modulators.Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.