TargetMol

Beta-Hydroxyisovalerylshikonin

Product Code:
 
TAR-TN1440
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-TN1440-1mg1mg£182.00
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TAR-TN1440-5mg5mg£412.00
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TAR-TN1440-10mg10mg£567.00
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TAR-TN1440-25mg25mg£843.00
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TAR-TN1440-50mg50mg£1,107.00
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Further Information

Bioactivity:
Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly decreased viability of HCT116 cells (IC50 values = 30.9 μg/mL).
CAS:
7415-78-3
Formula:
C21H24O7
Molecular Weight:
388.416
Pathway:
Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; GPCR/G Protein; Metabolism; Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
Purity:
0.9816
SMILES:
CC(C)=CC[C@@H](OC(=O)CC(C)(C)O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
Target:
EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase

References

Vukic MD, et al. Antibacterial and cytotoxic activities of naphthoquinone pigments from Onosma visianii Clem. EXCLI J. 2017 Feb 16;16:73-88. Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93(8):944-51. Chen X , et al. ?-Hydroxyisovalerylshikonin inhibits IL-1?-induced chondrocyte inflammation via Nrf2 and retards osteoarthritis in mice. Food Funct. 2020 Nov 18;11(11):10219-10230.