TargetMol

Vardenafil

Product Code:
 
TAR-T0096
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0096-25mg25mg£111.00
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TAR-T0096-100mg100mg£128.00
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TAR-T0096-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T0096-200mg200mg£179.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.
CAS:
224785-90-4
Formula:
C23H32N6O4S
Molecular Weight:
488.61
Pathway:
Metabolism
Purity:
0.98
SMILES:
CCCc1nc(C)c2c(O)nc(nn12)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Target:
PDE

References

1. Saenz de Tejada I, et al. Int J Impot Res, 2001, 13(5), 282-290.