TargetMol

Zonisamide

Product Code:
 
TAR-T0267
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0267-50mg50mg£103.00
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Quantity:
TAR-T0267-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0267-100mg100mg£118.00
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TAR-T0267-200mg200mg£134.00
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TAR-T0267-500mg500mg£178.00
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Further Information

Bioactivity:
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels results in a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may lower the uptake of the inhibitory neurotransmitter GABA while increasing the uptake of the excitatory neurotransmitter glutamate.
CAS:
68291-97-4
Formula:
C8H8N2O3S
Molecular Weight:
212.22
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.9994
SMILES:
NS(=O)(=O)Cc1noc2ccccc12
Target:
Calcium Channel; Sodium Channel; Carbonic Anhydrase

References

1. Sonsalla PK, et al. Exp Neurol, 2010, 221(2), 329-334. 2. Tanabe M, et al. Naunyn Schmiedebergs Arch Pharmacol, 2005, 372(2), 107-114. 3. Hayakawa T, et al. Eur J Pharmacol, 1994, 257(1-2), 131-136. 4. Ueda Y, et al. Brain Res Mol Brain Res, 2003, 116(1-2), 1-6. 5. Okada M, et al. Br J Pharmacol, 1998, 124(6), 1277-1285. 6. Tian J, Wu Q, He Y, et al. Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress[J]. Acta Pharmacologica Sinica. 2020: 1-11.