TargetMol

ATX inhibitor 5

Product Code:
 
TAR-T10409
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10409-1mg1mg£164.00
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TAR-T10409-5mg5mg£303.00
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TAR-T10409-1mL1 mL * 10 mM (in DMSO)£307.00
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TAR-T10409-10mg10mg£454.00
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TAR-T10409-25mg25mg£704.00
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TAR-T10409-50mg50mg£938.00
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TAR-T10409-100mg100mg£1,259.00
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TAR-T10409-500mg500mg£2,456.00
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Further Information

Bioactivity:
ATX inhibitor 5 is an orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM). It has an anti-hepatofibrosis effect and reduces CCl4-induced hepatic fibrosis level prominently.
CAS:
2402772-45-4
Formula:
C22H18ClF3N6O
Molecular Weight:
474.87
Pathway:
Metabolism
Purity:
0.98
SMILES:
FC(F)(F)c1cccc(Nc2ncnc3CCN(Cc23)C(=O)NN=Cc2ccc(Cl)cc2)c1
Target:
PDE

References

1. Jiang?N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem.?2020 Feb 1;187:111904.