TargetMol

AZ505 ditrifluoroacetate

Product Code:
 
TAR-T10427
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
CAS:
1035227-44-1
Formula:
C33H40Cl2F6N4O8
Molecular Weight:
805.59
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.Oc1ccc(CCNCCN(C2CCCCC2)C(=O)CCNCCc2ccc(Cl)c(Cl)c2)c2OCC(=O)Nc12
Target:
Histone Methyltransferase

References

1. Komatsu S, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015 Jan 20;112(2):357-64. 2. Ferguson AD, et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.