TargetMol

GNF362

Product Code:
 
TAR-T11446
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11446-5mg5mg£304.00
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TAR-T11446-50mg50mg£1,163.00
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Quantity:
TAR-T11446-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNF362 is a selective and orally bioavailable inhibitor of inositol trisphosphate 3? kinase B (Itpkb; IC50: 9 nM). GNF362 also inhibits Itpka and Itpkc (IC50s: 20 nM and 19 nM).
CAS:
1003019-41-7
Formula:
C22H21F3N6
Molecular Weight:
426.447
Purity:
0.98
SMILES:
C[C@@H]1CN(Cc2cn[nH]c2-c2ccc(cc2)C#N)CCN1c1ccc(cn1)C(F)(F)F

References

1. Miller AT, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.