TargetMol

HPN-01

Product Code:
 
TAR-T11573
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11573-5mg5mg£270.00
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TAR-T11573-50mg50mg£1,026.00
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Quantity:
TAR-T11573-100mg100mg£1,564.00
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Further Information

Bioactivity:
HPN-01 is a selective IKK inhibitor (pIC50s: 6.4, 7.0, and <4.8 for IKK-α, IKK-β, and IKK-ε). HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, ErbB2, EGFR, GSK3β, Src, PLK1, and VEGFR-2.
CAS:
928655-63-4
Formula:
C19H16ClN3O3S
Molecular Weight:
401.87
Purity:
0.98
SMILES:
NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1

References

1. Christopher JA, et al. The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3972-7. 2. Ke Li, et al. Amino-aryl-benzamide compounds and methods of use thereof.WO2018204775A1.