TargetMol

PF-06751979

Product Code:
 
TAR-T12429
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12429-100mg100mgEnquire
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TAR-T12429-50mg50mg£1,364.00
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TAR-T12429-5mg5mg£1,989.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
CAS:
1818339-66-0
Formula:
C18H19F2N5O3S2
Molecular Weight:
455.5
Pathway:
Neuroscience
Purity:
0.98
SMILES:
[H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1
Target:
BACE

References

1. O'Neill BT, et al. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ?-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61(10):4476-4504.