TargetMol

RIPK1-IN-4

Product Code:
 
TAR-T12730
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12730-1mg1mg£164.00
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Quantity:
TAR-T12730-1mL1 mL * 10 mM (in DMSO)£274.00
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TAR-T12730-5mg5mg£302.00
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TAR-T12730-10mg10mg£436.00
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TAR-T12730-25mg25mg£675.00
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Quantity:
TAR-T12730-50mg50mg£922.00
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Quantity:
TAR-T12730-100mg100mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).
CAS:
1481641-08-0
Formula:
C23H23N5O2
Molecular Weight:
401.47
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cccc3c(N)nccc23)no1
Target:
TNF

References

1. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.