TargetMol

Tankyrase-IN-2

Product Code:
 
TAR-T13078
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13078-5mg5mg£337.00
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TAR-T13078-50mg50mg£1,532.00
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Quantity:
TAR-T13078-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
CAS:
1588870-36-3
Formula:
C17H14F2N2O2
Molecular Weight:
316.308
Pathway:
Cytoskeletal Signaling; Stem Cells
Purity:
0.98
SMILES:
CC(C)(O)c1ccc(cc1)-c1nc2c(F)cc(F)cc2c(=O)[nH]1
Target:
Wnt/beta-catenin

References

1. Buchstaller HP, et al. Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective TankyraseInhibitor Modulating Wnt Pathway Activity. J Med Chem. 2019 Aug 5.