TargetMol

XL-784

Product Code:
 
TAR-T13358
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13358-5mg5mg£304.00
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TAR-T13358-50mg50mg£1,163.00
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Quantity:
TAR-T13358-100mg100mg£1,669.00
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This product comes from: United States.
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Further Information

Bioactivity:
XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
CAS:
1224964-36-6
Formula:
C21H22ClF2N3O8S
Molecular Weight:
549.93
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
O=C(N1CC(C(NO)=O)N(S(=O)(C2=CC(F)=C(OC3=CC=C(Cl)C=C3)C(F)=C2)=O)CC1)OCCOC.[0.5Mg2+]
Target:
MMP

References

1. Williams JM, et al. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol. 2011 Apr;300(4):F983-98. 2. Ennis T, et al. Effect of novel limited-spectrum MMP inhibitor XL784 in abdominal aortic aneurysms. J Cardiovasc Pharmacol Ther. 2012 Dec;17(4):417-26.