TargetMol

AKOS-22

Product Code:
 
TAR-T14150
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14150-5mg5mg£850.00
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TAR-T14150-50mg50mg£1,661.00
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TAR-T14150-100mg100mg£2,079.00
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Further Information

Bioactivity:
AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis.
CAS:
878983-38-1
Formula:
C22H21ClF3N3O3
Molecular Weight:
467.87
Purity:
0.98
SMILES:
FC(F)(F)Oc1ccc(NC2CCN(CC2)C2CC(=O)N(C2=O)c2ccc(Cl)cc2)cc1

References

1. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protectagainst Mitochondrial Dysfunction. Biol Chem. 2016 Nov 25;291(48):24986-25003.