TargetMol

Apratastat

Product Code:
 
TAR-T14312
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T14312-5mg5mg£270.00
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TAR-T14312-50mg50mg£833.00
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TAR-T14312-100mg100mg£1,219.00
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Further Information

Bioactivity:
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
CAS:
287405-51-0
Formula:
C17H22N2O6S2
Molecular Weight:
414.49
Pathway:
Proteases/Proteasome; Apoptosis
Purity:
0.98
SMILES:
CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Target:
MMP; TNF

References

1. Shu C, et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. J Clin Pharmacol. 2011 Apr;51(4):472-81.