TargetMol

Butyrolactone 3

Product Code:
 
TAR-T14839
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14839-50mg50mg£804.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T14839-100mg100mg£1,171.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
Butyrolactone 3 is a specifical inhibitor of the histone acetyltransferase Gcn5 (IC50: 100 μM) with a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50: 0.5 mM).
CAS:
778649-18-6
Formula:
C9H12O4
Molecular Weight:
184.191
Purity:
0.98
SMILES:
CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

References

1. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6