Larotaxel

Product Code:

TAR-T15713

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T15713-25mg

25mg

£744.00

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Quantity:

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Further Information

Bioactivity:

Larotaxel is a taxane analogue with preclinical activity against taxane-resistant breast cancer. It can cross the blood-brain barrier and has a much lower affinity for P-glycoprotein 1. Larotaxel promotes tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis.

CAS:

156294-36-9

Formula:

C45H53NO14

Molecular Weight:

831.912

Purity:

0.98

SMILES:

[H][C@@]12C[C@@H]3C[C@@]33C(=O)[C@]([H])(OC(C)=O)C4=C(C)[C@@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1

Documents

References

1. Di?ras V, et al. Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy. Ann Oncol. 2008 Jul;19(7):1255-60. 2. Morris PG, et al. Novel anti-tubulin cytotoxic agents for breast cancer. Expert Rev Anticancer Ther. 2009 Feb;9(2):175-85. 3. Zatloukal P, et al. Randomized multicenter phase II study of larotaxel (XRP9881) in combination with cisplatin or gemcitabine as first-line chemotherapy in nonirradiable stage IIIB or stage IV non-small cell lung cancer. J Thorac Oncol. 2008 Aug;3(8):894-901.