TargetMol

Tandutinib

Product Code:
 
TAR-T1667
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1667-25mg25mg£101.00
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TAR-T1667-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T1667-50mg50mg£114.00
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TAR-T1667-100mg100mg£129.00
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TAR-T1667-200mg200mg£152.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tandutinib (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR.
CAS:
387867-13-2
Formula:
C31H42N6O4
Molecular Weight:
562.715
Pathway:
Apoptosis; Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9983
SMILES:
COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Target:
Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit

References

1. Kelly LM, et al. Cancer Cell, 2002, 1(5), 421-432. 2. Griswold IJ, et al. Blood, 2004, 104(9), 2912-2918. 3. Schittenhelm MM, et al. Cell Cycle, 2009, 8(16), 2621-2630.