TargetMol

Rupintrivir

Product Code:
 
TAR-T16809
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16809-5mg5mg£301.00
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Quantity:
TAR-T16809-50mg50mg£1,026.00
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Quantity:
TAR-T16809-100mg100mg£1,508.00
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This product comes from: United States.
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Further Information

Bioactivity:
Rupintrivirvr is an effective and irreversible inhibitor of human rhinovirus 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays (EC50: 0.023 μM). Rupintrivirvr displays the immune-modulatory effect.
CAS:
223537-30-2
Formula:
C31H39FN4O7
Molecular Weight:
598.672
Purity:
0.98
SMILES:
CCOC(=O)C=C[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@@H](CC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C)Cc1ccc(F)cc1

References

1. Patick AK, et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50. 2. Danov O, et al. Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res. 2019 Oct 22;20(1):228. 3. Dragovich PS, et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem. 1999 Apr 8;42(7):1203-12.