TargetMol

SAFit2

Product Code:
 
TAR-T16836
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16836-1mg1mg£135.00
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TAR-T16836-5mg5mg£229.00
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TAR-T16836-1mL1 mL * 10 mM (in DMSO)£281.00
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TAR-T16836-10mg10mg£309.00
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TAR-T16836-25mg25mg£466.00
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TAR-T16836-50mg50mg£647.00
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Quantity:
TAR-T16836-100mg100mg£868.00
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This product comes from: United States.
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Further Information

Bioactivity:
SAFit2 is a highly potent and selective FK506-binding protein 51 inhibitor (Ki: 6 nM) and also enhances AKT2-AS160 binding.
CAS:
1643125-33-0
Formula:
C46H62N2O10
Molecular Weight:
803.006
Pathway:
Autophagy
Purity:
0.98
SMILES:
COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C2CCCCC2)c2cc(OC)c(OC)c(OC)c2)c2cccc(OCCN3CCOCC3)c2)cc1OC
Target:
FKBP

References

1. Gaali S, et al. Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. J Med Chem. 2016 Mar 24;59(6):2410-22. 2. Balsevich G, et al. Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun. 2017 Nov 23;8(1):1725. 3. Hartmann J, et al. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. J Neurosci. 2015 Jun 17;35(24):9007-16.