TargetMol

SB228357

Product Code:
 
TAR-T16856
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16856-1mg1mg£164.00
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TAR-T16856-1mL1 mL * 10 mM (in DMSO)£297.00
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TAR-T16856-5mg5mg£309.00
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TAR-T16856-10mg10mg£483.00
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TAR-T16856-25mg25mg£728.00
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TAR-T16856-50mg50mg£946.00
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Quantity:
TAR-T16856-100mg100mg£1,267.00
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This product comes from: United States.
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Further Information

Bioactivity:
SB228357 is a selective and potent 5-HT2C/2B receptor antagonist (pKi: 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively).
CAS:
181629-93-6
Formula:
C22H17F4N3O2
Molecular Weight:
431.391
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.98
SMILES:
COc1cc2CCN(C(=O)Nc3cc(F)cc(c3)-c3cccnc3)c2cc1C(F)(F)F
Target:
5-HT Receptor

References

1. Bromidge SM, et al. Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. 2. Reavill C, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4.