TargetMol

TC-I 2014

Product Code:
 
TAR-T17006
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17006-1mg1mg£164.00
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TAR-T17006-5mg5mg£301.00
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TAR-T17006-10mg10mg£414.00
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TAR-T17006-25mg25mg£621.00
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TAR-T17006-50mg50mg£849.00
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TAR-T17006-100mg100mg£1,099.00
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TAR-T17006-500mg500mg£2,175.00
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Further Information

Bioactivity:
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).
CAS:
1221349-53-6
Formula:
C23H19F6N3O
Molecular Weight:
467.415
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
Target:
TRP/TRPV Channel

References

1. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.