TargetMol

Tonapofylline

Product Code:
 
TAR-T17117
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17117-1mg1mg£119.00
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TAR-T17117-5mg5mg£189.00
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TAR-T17117-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T17117-10mg10mg£261.00
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TAR-T17117-25mg25mg£453.00
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TAR-T17117-50mg50mg£626.00
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TAR-T17117-100mg100mg£860.00
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Further Information

Bioactivity:
Tonapofylline is an orally active and selective antagonist of the A1 adenosine receptor (Ki: 7.4 nM for human A1). Tonapofylline can be used in studies about heart failure.
CAS:
340021-17-2
Formula:
C22H32N4O4
Molecular Weight:
416.51
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9952
SMILES:
O=C(O)CCC12CCC(C3=NC4=C(N3)C(=O)N(C(=O)N4CCC)CCC)(CC1)CC2
Target:
Adenosine Receptor

References

Kiesman WF, et al. Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30;49(24):7119-31. Ensor CR, et al. Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment of heart failure. Expert Opin Pharmacother. 2010 Oct;11(14):2405-15. Gill A, et al. Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against cisplatin-induced acute kidney injury in rats. Am J Nephrol. 2009;30(6):521-6.