TargetMol

Inflachromene

Product Code:
 
TAR-T24167
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24167-5mg5mg£303.00
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TAR-T24167-50mg50mg£1,131.00
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Quantity:
TAR-T24167-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
Inflachromene is an inhibitor of microglial. It acts by binding HMGB1 and HMGB2 and inhibiting microglia-mediated neuroinflammation.
CAS:
908568-01-4
Formula:
C21H19N3O4
Molecular Weight:
377.4
Purity:
0.98
SMILES:
CC1(C)Oc2cc(O)ccc2C2C1=CCn1n2c(=O)n(-c2ccccc2)c1=O

References

1. Kim YH, Kwak MS, Shin JM, Hayuningtyas RA, Choi JE, Shin JS. Inflachromene inhibits autophagy through modulation of Beclin 1 activity. J Cell Sci. 2018 Feb 20;131(4). pii: jcs211201. doi: 10.1242/jcs.211201. PubMed PMID: 29361549. 2. Zhao Y, Yang Z, Wu J, Wu R, Keshipeddy SK, Wright D, Wang L. High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells. Hepatol Commun. 2017 Oct;1(8):816-830. doi: 10.1002/hep4.1086. Epub 2017 Aug 28. PubMed PMID: 29218329; PubMed Central PMCID: PMC5678910. 3. Cho W, Koo JY, Park Y, Oh K, Lee S, Song JS, Bae MA, Lim D, Lee DS, Park SB. Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents. J Med Chem. 2017 Jan 12;60(1):170-179. doi: 10.1021/acs.jmedchem.6b00954. Epub 2016 Dec 21. PubMed PMID: 28001381. 4. Block ML. Neuroinflammation: modulating mighty microglia. Nat Chem Biol. 2014 Dec;10(12):988-9. doi: 10.1038/nchembio.1691. PubMed PMID: 25393492.