TargetMol

Cilastatin

Product Code:
 
TAR-T2583
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2583-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T2583-25mg25mg£116.00
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TAR-T2583-50mg50mg£136.00
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TAR-T2583-100mg100mg£172.00
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TAR-T2583-200mg200mg£238.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
CAS:
82009-34-5
Formula:
C16H26N2O5S
Molecular Weight:
358.45
Pathway:
Ubiquitination; Proteases/Proteasome; Microbiology/Virology
Purity:
0.9971
SMILES:
S(C[C@H](N)C(=O)O)CCCC/C=C(NC(=O)[C@@H]1C(C1)(C)C)/C(=O)O
Target:
Proteasome; Antibacterial; Antibiotic

References

1. Farrell CA, et al. Arch Biochem Biophys. 1987 Jul;256(1):253-9. 2. Huo X, Meng Q, Wang C, et al. Protective effect of cilastatin against diclofenac?induced nephrotoxicity in mice through interaction with diclofenac acyl glucuronide via OATs[J]. British Journal of Pharmacology. 2020, 177(9): 1933-1948.