TargetMol

Eflornithine hydrochloride hydrate

Product Code:
 
TAR-T2593
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T2593-50mg50mg£95.00
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Quantity:
TAR-T2593-100mg100mg£104.00
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TAR-T2593-200mg200mg£117.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T2593-500mg500mg£170.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.
CAS:
96020-91-6
Formula:
C6H15ClF2N2O3
Molecular Weight:
236.64
Pathway:
; Metabolism
Purity:
0.9964
SMILES:
O.Cl.NCCCC(N)(C(F)F)C(O)=O
Target:
Decarboxylase

References

1. Yoda H, et al. Plant Physiol. 2006, 142(1):193-206. 2. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. 3. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. 4. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. 5. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. 6. Dial C N. Modulation of Coxsackievirus Protease Activity by Polyamines[D]. Loyola University Chicago. 2019. 7. Dial C N, Tate P M, Kicmal T M, et al. Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity[J]. Viruses. 2019 Apr 30;11(5). 8. Kicmal T M, Tate P M, Dial C N, et al. Polyamine depletion abrogates enterovirus cellular attachment[J]. Journal of virology. 2019, 93(20): e01054-19. 9. Mastrodomenico V, Esin J J, Graham M L, et al. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions[J]. Journal of virology. 2019 May 1. pii: JVI.00530-19.