TargetMol

CL075

Product Code:
 
TAR-T27034
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
CL-075 is a TLR8 agonist.
CAS:
256922-53-9
Formula:
C13H13N3S
Molecular Weight:
243.33
Pathway:
NF-κb|Immunology/Inflammation
Purity:
0.98
SMILES:
CCCc1nc2c(N)nc3ccccc3c2s1
Target:
NF-κB|TLR|MyD88

References

1. Pang M, Bala S, Kodys K, Catalano D, Szabo G. Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 2011 Sep 30;12:55. doi: 10.1186/1471-2172-12-55. PubMed PMID: 21962237; PubMed Central PMCID: PMC3203086. 2. Du M, Butchi NB, Woods T, Peterson KE. Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8. PLoS One. 2011;6(7):e22454. doi: 10.1371/journal.pone.0022454. Epub 2011 Jul 21. PubMed PMID: 21811614; PubMed Central PMCID: PMC3141064. 3. Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O. The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One. 2013;8(3):e58164. doi: 10.1371/journal.pone.0058164. Epub 2013 Mar 4. PubMed PMID: 23483986; PubMed Central PMCID: PMC3587566. 4. Elavazhagan S, Fatehchand K, Santhanam V, Fang H, Ren L, Gautam S, Reader B, Mo X, Cheney C, Briercheck E, Vasilakos JP, Dietsch GN, Hershberg RM, Caligiuri M, Byrd JC, Butchar JP, Tridandapani S. Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. J Immunol. 2015 Mar 15;194(6):2786-95. doi: 10.4049/jimmunol.1402316. Epub 2015 Feb 9. PubMed PMID: 25667415; PubMed Central PMCID: PMC4355383.