TargetMol

ER819762

Product Code:
 
TAR-T27279
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27279-5mg5mg£850.00
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Quantity:
TAR-T27279-50mg50mg£1,661.00
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Quantity:
TAR-T27279-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
CAS:
1155773-15-1
Formula:
C30H39N3O3
Molecular Weight:
489.66
Purity:
0.98
SMILES:
CCN1C(=O)C2=CCc3cc(OC)cc(OC)c3[C@H](C)N2C11CCN(Cc2cc(C)cc(C)c2)CC1

References

1. Jones VC, Birrell MA, Maher SA, Griffiths M, Grace M, O'Donnell VB, Clark SR, Belvisi MG. Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2. Br J Pharmacol. 2016 Mar;173(6):992-1004. doi: 10.1111/bph.13400. PubMed PMID: 26639895; PubMed Central PMCID: PMC4831025. 2. Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M, Li W, Inoue Y, Ackermann K, Shirota H, Matsumoto I, Spyvee M, Schiller S, Sumida T, Gusovsky F, Lamphier M. A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol. 2010 May;160(2):292-310. doi: 10.1111/j.1476-5381.2010.00647.x. PubMed PMID: 20423341; PubMed Central PMCID: PMC2874852.