TargetMol

Furamidine dihydrochloride

Product Code:
 
TAR-T27395
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T27395-5mg5mg£244.00
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TAR-T27395-50mg50mg£728.00
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TAR-T27395-100mg100mg£1,058.00
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Further Information

Bioactivity:
Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA?s minor groove. Furamidine targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furthermore, Furamidine blocks cell proliferation in leukemia cell lines with different genetic lesions.
CAS:
55368-40-6
Formula:
C18H18Cl2N4O
Molecular Weight:
377.27
Purity:
0.98
SMILES:
Cl.Cl.NC(=N)c1ccc(cc1)-c1ccc(o1)-c1ccc(cc1)C(N)=N

References

1. Sauer B, Skinner-Adams TS, Bouchut A, Chua MJ, Pierrot C, Erdmann F, Robaa D, Schmidt M, Khalife J, Andrews KT, Sippl W. Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum. Eur J Med Chem. 2017 Feb 15;127:22-40. doi: 10.1016/j.ejmech.2016.12.041. Epub 2016 Dec 23. PubMed PMID: 28038325. 2. Yang G, Choi G, No JH. Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6828-6836. doi: 10.1128/AAC.01129-16. Print 2016 Nov. PubMed PMID: 27600039; PubMed Central PMCID: PMC5075092. 3. Siboni RB, Bodner MJ, Khalifa MM, Docter AG, Choi JY, Nakamori M, Haley MM, Berglund JA. Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models. J Med Chem. 2015 Aug 13;58(15):5770-80. doi: 10.1021/acs.jmedchem.5b00356. Epub 2015 Jul 21. PubMed PMID: 26103061; PubMed Central PMCID: PMC4972181. 4. Coles JA, Myburgh E, Ritchie R, Hamilton A, Rodgers J, Mottram JC, Barrett MP, Brewer JM. Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Negl Trop Dis. 2015 Apr 16;9(4):e0003714. doi: 10.1371/journal.pntd.0003714. eCollection 2015 Apr. PubMed PMID: 25881126; PubMed Central PMCID: PMC4400075.