TargetMol

HTL14242

Product Code:
 
TAR-T27560
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27560-5mg5mg£304.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T27560-50mg50mg£1,203.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27560-100mg100mg£1,669.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
HTL14242 is a mGlu5 Negative Allosteric Modulator.
CAS:
1644645-32-8
Formula:
C16H8ClFN4
Molecular Weight:
310.72
Purity:
0.98
SMILES:
Fc1ccc(nc1)-c1cc(ncn1)-c1cc(Cl)cc(c1)C#N

References

1. Christopher JA, Aves SJ, Bennett KA, Dor? AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M. Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J Med Chem. 2015 Aug 27;58(16):6653-64. doi: 10.1021/acs.jmedchem.5b00892. PubMed PMID: 26225459. 2. Topiol S, Sabio M. 7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5. Bioorg Med Chem Lett. 2016 Jan 15;26(2):484-94. doi: 10.1016/j.bmcl.2015.11.087. PubMed PMID: 26706173. 3. Tehan BG, Christopher JA. The use of conformationally thermostabilised GPCRs in drug discovery: application to fragment, structure and biophysical techniques. Curr Opin Pharmacol. 2016 Oct;30:8-13. doi: 10.1016/j.coph.2016.06.010. Review. PubMed PMID: 27400445.