TargetMol

VU6001966

Product Code:
 
TAR-T29142
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29142-5mg5mg£850.00
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Quantity:
TAR-T29142-50mg50mg£1,661.00
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Quantity:
TAR-T29142-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration.
CAS:
2009052-76-8
Formula:
C17H15FN4O2
Molecular Weight:
326.331
Purity:
0.98
SMILES:
Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1

References

1. Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA. Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. J Med Chem. 2015 Nov 25;58(22):9027-40. doi: 10.1021/acs.jmedchem.5b01371. Epub 2015 Nov 11. PubMed PMID: 26524606; PubMed Central PMCID: PMC4817271. 2. Bollinger KA, Felts AS, Brassard CJ, Engers JL, Rodriguez AL, Weiner RL, Hyekyung PC, Chang S, Bubser M, Jones CK, Blobaum AL, Niswender CM, Conn JP, Emmitte KA, Lindsley CW. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. ACS Med Chem. 2017 Aug 3. doi: 10.1021/acsmedchemlett.7b00279. [Epub ahead of print].