TargetMol

(E)-5-(2-Bromovinyl)uracil

Product Code:
 
TAR-T35439
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35439-25mg25mg£310.00
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TAR-T35439-50mg50mg£458.00
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Quantity:
TAR-T35439-100mg100mg£681.00
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This product comes from: United States.
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Further Information

Bioactivity:
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
CAS:
69304-49-0
Formula:
C6H5BrN2O2
Molecular Weight:
217.022
Purity:
0.98
SMILES:
BrC=Cc1c[nH]c(=O)[nH]c1=O