TargetMol

IHMT-PI3Kδ-372

Product Code:
 
TAR-T35530
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35530-1mg1mg£132.00
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TAR-T35530-5mg5mg£222.00
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TAR-T35530-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T35530-10mg10mg£309.00
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TAR-T35530-25mg25mg£464.00
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TAR-T35530-50mg50mg£655.00
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Quantity:
TAR-T35530-100mg100mg£863.00
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This product comes from: United States.
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Further Information

Bioactivity:
IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.
CAS:
2429889-62-1
Formula:
C26H23F2N7O2
Molecular Weight:
503.5
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
[C@H](CC)(N1C=2C(C(=N1)C3=CC(F)=C(OC)C=C3)=C(N)N=CN2)C=4N(C(=O)C=5C(N4)=CC=CC5F)C6CC6
Target:
PI3K

References

Feng Li, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1 H-pyrazolo[3,4- d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3 H)-one (IHMT-PI3K?-372) as a Potent and Selective PI3K? Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.