TargetMol

T-5342126

Product Code:
 
TAR-T35864
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35864-5mg5mg£850.00
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TAR-T35864-50mg50mg£1,661.00
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TAR-T35864-100mg100mg£2,079.00
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Further Information

Bioactivity:
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.2
CAS:
956507-49-6
Formula:
C25H32ClN3O3
Molecular Weight:
458
Purity:
0.98
SMILES:
CN(CC(COC1=CC=C(C=C1)OCC)O)CC2=C(C)N(CC3=CC=CC=C3Cl)N=C2C

References

Chavez, S.A., Martinko, A.J., Lau, C., et al.Development of ?-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antisepticsJ. Med. Chem.54(13)4659-4669(2011) Bajo, M., Montgomery, S.E., Cates, L.N., et al.Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent miceAlcohol Alcohol.51(5)541-548(2016)