TargetMol

MitoPBN

Product Code:
 
TAR-T35962
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35962-5mg5mg£850.00
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TAR-T35962-50mg50mg£1,661.00
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Quantity:
TAR-T35962-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
CAS:
652968-37-1
Formula:
C33H37NO2P?Br
Molecular Weight:
590.5
Purity:
0.98
SMILES:
CC(C)(C)/[N+]([O-])=C/C(C=C1)=CC=C1OCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]