TargetMol

5 α,6 α-epoxy Cholestanol

Product Code:
 
TAR-T35973
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35973-50mg50mg£125.00
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TAR-T35973-100mg100mg£173.00
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TAR-T35973-200mg200mg£240.00
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This product comes from: United States.
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Further Information

Bioactivity:
5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.[1] 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ). [2] 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.[1] Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer?s disease. [3]
CAS:
1250-95-9
Formula:
C27H46O2
Molecular Weight:
402.663
Purity:
0.98
SMILES:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C[C@@H]4O[C@@]44C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

References

Segala, G., de Medina, P., Iuliano, L., et al. 5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells. Biochem. Pharmacol. 86(1), 175-189 (2013). Testa, G., Staurenghi, E., Zerbinati, C., et al. Changes in brain oxysterols at different stages of Alzheimer?s disease: Their involvement in neuroinflammation. Redox Biol. 10, 24-33 (2016). Villalpando, D.M., Rojas, M.M., Garc?a, H.S., et al. Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. PLoS One 12(10), e0185805 (2017).