TargetMol

N1-Acetylspermine (hydrochloride)

Product Code:
 
TAR-T36416
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36416-25mg25mg£390.00
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Quantity:
TAR-T36416-50mg50mg£631.00
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Further Information

Bioactivity:
N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. [1] Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. [2][3] N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.[4]
CAS:
77928-70-2
Formula:
C12H31Cl3N4O
Molecular Weight:
353.76
Purity:
0.98
SMILES:
Cl.Cl.Cl.CC(=O)NCCCNCCCCNCCCN

References

Igarashi, K, et al Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000). Aouida, et al. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. The Journal of Biological Chemisty 285(9), 6275-6284 (2010). Gutierrez, et al. Mechanisms of spermine- and N1-acetylspermine-induced relaxation on rat uterine smooth muscle in-vitro.Pharmaceutical Sciences, 1997, vol. 3, # 10, p. 513 - 516 Bolkenius, F.N, et al. Acetylderivatives as intermediates in polyamine catabolism. International Journal of Biochemistry 13(3), 287-292 (1981).