TargetMol

CMLD-2

Product Code:
 
TAR-T36493
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36493-1mg1mg£149.00
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TAR-T36493-5mg5mg£269.00
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TAR-T36493-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T36493-10mg10mg£402.00
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TAR-T36493-25mg25mg£613.00
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TAR-T36493-50mg50mg£828.00
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TAR-T36493-100mg100mg£1,091.00
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TAR-T36493-500mg500mg£2,103.00
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Further Information

Bioactivity:
CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2].
CAS:
958843-91-9
Formula:
C31H31NO6
Molecular Weight:
513.59
Pathway:
Apoptosis
Purity:
0.98
SMILES:
COc1ccc(cc1)C(CC(=O)N1CCCC1)c1c(OC)cc(OC)c2c(cc(=O)oc12)-c1ccccc1
Target:
Apoptosis

References

Kunder N, et al. The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans. J Neurosci. 2022 ; 42(49):9129-9141. Prikrylov? V, et al. Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone. J Antibiot (Tokyo). 1985 ; 38(12):1714-1718. Wu X, et al. Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol. 2015 ; 10(6):1476-1484. Allegri L, et al. The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. Sci Rep. 2019 ; 9(1):7374. Muralidharan R, et al. HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. Sci Rep. 2017 ; 7(1):9694.