TargetMol

DS44960156

Product Code:
 
TAR-T37655
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37655-25mg25mg£630.00
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TAR-T37655-50mg50mg£970.00
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Further Information

Bioactivity:
DS44960156 is an inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2; IC50= 1.6 μM).1It is selective for MTHFD2 over MTHFD1 (IC50= >30 μM).
CAS:
2361327-08-2
Formula:
C20H15NO5
Molecular Weight:
349.3
Purity:
0.98
SMILES:
O=C1C2=C(CCN(C(C3=CC=C(C(O)=O)C=C3)=O)C2)C4=C(C=CC=C4)O1

References

Kawai, J., Ota, M., Ohki, H., et al.Structure-based design and synthesis of an isozyme-selective MTHFD2 inhibitor with a tricyclic coumarin scaffoldACS Med. Chem. Lett.10(6)893-898(2019)