TargetMol

5(6)-Carboxy-2?,7?-dichlorofluorescein diacetate

Product Code:
 
TAR-T38123
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38123-25mg25mg£238.00
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TAR-T38123-50mg50mg£318.00
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TAR-T38123-100mg100mg£439.00
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Further Information

Bioactivity:
5(6)-Carboxy-2?,7?-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2?,7?,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production.
CAS:
127770-45-0
Formula:
C25H14Cl2O9
Molecular Weight:
529.3
Purity:
0.98
SMILES:
O=C(O1)C2=C(C=CC(C(O)=O)=C2)C31C4=CC(Cl)=C(OC(C)=O)C=C4OC5=C3C=C(Cl)C(OC(C)=O)=C5.O=C(O6)C7=C(C=C(C(O)=O)C=C7)C86C9=CC(Cl)=C(OC(C)=O)C=C9OC%10=C8C=C(Cl)C(OC(C)=O)=C%10

References

Hempel, S.L., Buettner, G.R., O?Malley, Y.Q., et al.Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2?,7?-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2?,7?-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123Free Radic. Biol. Med.27(1-2)146-159(1999)