TargetMol

CU-32

Product Code:
 
TAR-T38328
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38328-5mg5mg£850.00
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Quantity:
TAR-T38328-50mg50mg£1,661.00
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Quantity:
TAR-T38328-100mg100mg£2,079.00
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Further Information

Bioactivity:
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.
CAS:
2400954-16-5
Formula:
C11H10IN5O2
Molecular Weight:
371.1
Purity:
0.98
SMILES:
IC1=CC=C(NC2=NC(N)=NC(C(OC)=O)=N2)C=C1

References

Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)