TargetMol

R-8507

Product Code:
 
TAR-T38339
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38339-5mg5mg£850.00
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Quantity:
TAR-T38339-50mg50mg£1,661.00
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Quantity:
TAR-T38339-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
CAS:
338773-13-0
Formula:
C16H8ClF3N4
Molecular Weight:
348.71
Purity:
0.98
SMILES:
FC(F)(F)c1nc2ccccc2n2c(nnc12)-c1ccc(Cl)cc1